A question summarizing RBV approach. Definition The resource-based view RBV is a model that sees resources as key to superior firm performance. If a resource exhibits VRIO attributes, the resource enables the firm to gain and sustain competitive advantage.
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Abstract In recent years, autoantibodies targeting subcellular structures described as the rods and rings pattern in HEp-2 ANA have been presented as a unique case of autoantibody generation.
These rod and ring structures RR are at least partially composed of inosine monophosphate dehydrogenase type 2 IMPDH2and their formation can be induced in vitro by several small-molecule inhibitors, including some IMPDH2 inhibitors. There are presently a few hypotheses attempting to explain how antibodies targeting self-proteins are generated, including suggestions that apoptotic bodies, epigenetic modifications, or cross-reactivity between self-proteins and foreign proteins, known as molecular mimicry, may play a role in autoantibody generation 1.
three general themes in the RBV debate: (i) how do we define ‘competitive advantage’ in healthcare?; (ii) the contribution of macro level theory to understanding of KM; and (iii) the need to align theory across different analytic levels. Harvey and. The resource-based view (RBV) is a managerial framework used to determine the strategic resources with the potential to deliver comparative advantage to a firm. These resources can be exploited by the firm in order to achieve sustainable competitive advantage. Debate case based: Do we need resistance testing in HCV therapy to guide decision making? Pro 4 1a 2D+RBV Breakthrough V36M+Y56H M28T 45 4 3a SMV+SOF Relapse DK Di Maio Do we need resistance testing in HCV therapy to.
Anti-RR antibodies seem to have an additional stipulation that has been reported by several independent laboratories: This implies that anti-RR antibodies should be considered drug-induced autoantibodies, similar to previously documented cases of antinuclear and anti-histone antibodies in drug-induced lupus erythematosus, which has been demonstrated in both humans and mice 7.
The story of anti-RR antibodies becomes more compelling when one considers that when the RR ANA pattern was first observed, the antigenic filamentous and annular structures targeted by these antibodies were completely unfamiliar to the field.
In recent years, our laboratory and other laboratories, who stumbled upon the same structure in mammalian cells through different means, have begun to elucidate the structural and functional characteristics of these previously unknown autoantigens 8 — In the following sections, we present anti-RR antibodies as a human model for drug-induced autoantibody generation, as well as report recent findings on the unusual enzymatic polymers known as RR that are targeted by these antibodies.
Autoantigenic Rod and Ring Structures In order to properly discuss anti-RR as a human model of autoantibody generation, it is necessary to first present current knowledge of the novel targets of these antibodies, since the process of elucidation of the RR structures has only been ongoing for less than a decade.
Both forms are observed primarily in the cytoplasm, although generally smaller structures are regularly found in the nucleus under cellular conditions allowing for RR formation 5.
While it has been shown that RR are not associated with any known organelles, we have observed perinuclear rods that appear to wrap around or position along the cytoplasmic side of the nuclear membrane 28.
The primary target and major component of the RR structures is the enzyme inosine monophosphate dehydrogenase type 2 IMPDH2which functions primarily in the GTP biosynthesis pathway by catalyzing the rate-limiting conversion of inosine monophosphate into xanthosine monophosphate.Write an essay that critically evaluates the debate between the market-based view (MBV) and the resource-based view (RBV).
Using real world examples ( and earlier), why do you think this debate has yet to be resolved by strategists? objectivity of the debate, however, suffers from a lack of specificity regarding the terms “sustainable” and “temporary.” That is, the amount of time or duration of a sustained or RBV’s application to business-level (competitive) strategy.
In his article, Barney outlines the.
programmes is wide and subject to debate; however, most definitions include three key pillars of economic growth, ecological balance, The RBV perspective, developed by Wernerfelt () and extended by Barney The strategic value of corporate social responsibility: A relationship management framework for public relations practice.
While there are many debates and discourses related to the field of strategy, two dominant models have sufficed, Industrial Organisation (IO) model and Resource Based View (RBV) model. Proponents of boththe models have led intense debate for the viability, sustainability and competitive success of .
The resource-based view (RBV) of the firm has influenced the field of strategic human resource management (SHRM) in a number of ways. This paper explores the impact of the RBV on the theoretical and empirical development of SHRM.
It explores how the fields of strategy and. Debate case based: Do we need resistance testing in HCV therapy to guide decision making? Pro 4 1a 2D+RBV Breakthrough V36M+Y56H M28T 45 4 3a SMV+SOF Relapse DK Di Maio Do we need resistance testing in HCV therapy to.